Funxion Plus Drug Interactions

Pregabalin: ACE inhibitors: Potential pharmacologic interaction with ACE inhibitors (e.g., increased risk of developing angioedema).
Gabapentin: The rate of pregabalin's absorption was reduced by approximately 26% (single dose administration) and 18% (multiple dose administration) based on lower C_max values; however, the extent of pregabalin absorption was unaffected by gabapentin coadministration.
Lorazepam, oxycodone and alcohol: Pregabalin may potentiate the effects of alcohol and lorazepam. Pregabalin appears to be additive in the impairment of cognitive and gross motor function caused by oxycodone.
In postmarketing experience, there are reports of respiratory failure and coma in patients taking pregabalin alone or in combination with other CNS depressants.
Higher frequencies of weight gain and peripheral edema were reported in patients taking both pregabalin and a thiazolidinedione antidiabetic agent compared to patients taking either drug alone.
As the thiazolidinedione class of antidiabetic drugs or pregabalin can cause weight gain and/or fluid retention alone or together, possibly exacerbating or leading to heart failure, caution should be exercised when co-administering pregabalin and these drugs.
Mecobalamin: Metformin: Metformin may decrease the absorption of vitamin B₁₂, which may be reversed with oral calcium supplementation.
Cholestyramine, colestipol: Cholestyramine and colestipol may decrease the enterohepatic reabsorption of B₁₂.
Chloramphenicol, colchicine, H₂-antagonists, neomycin, para-aminosalicylic acid, proton-pump inhibitors (e.g., omeprazole): These drugs may decrease the absorption of vitamin B₁₂ from the gastrointestinal tract.
Nitrous oxide: Nitrous oxide forms a complex with cobalt in mecobalamin. Since mecobalamin is a cofactor of methionine synthase, inhalation of nitrous oxide may inactivate this enzyme.
Folate and vitamin B₆: Folic acid and vitamin B₆ may work synergistically with vitamin B₁₂ in lowering homocysteine levels.
Oral contraceptives: Oral contraceptives may reduce the serum concentration of vitamin B₁₂.
Most antibiotics, methotrexate, pyrimethamine: These drugs may invalidate folic acid and vitamin B₁₂ diagnostic blood assays.